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梅毒发病机制与疫苗设计中的迟发型超敏反应、免疫偏离、抗原加工及T细胞亚群选择

Delayed hypersensitivity, immune deviation, antigen processing and T-cell subset selection in syphilis pathogenesis and vaccine design.

作者信息

Sell S, Hsu P L

机构信息

Dept of Pathology, University of Texas Health Science Center, Houston 77030.

出版信息

Immunol Today. 1993 Dec;14(12):576-82. doi: 10.1016/0167-5699(93)90196-R.

DOI:10.1016/0167-5699(93)90196-R
PMID:8305130
Abstract

T-cell mediated delayed-type hypersensitivity (DTH) is the predominant immune mechanism for clearing tissues of infecting organisms in the primary lesion of syphilis. Here, Stewart Sell and Pei-Ling Hsu propose a strategy for vaccination against syphilis in which selective induction of DTH may be accomplished by using BCG vectored vaccines containing selected DNA sequences for T. pallidum antigens.

摘要

T细胞介导的迟发型超敏反应（DTH）是清除梅毒一期损害中感染组织内病原体的主要免疫机制。在此，斯图尔特·塞尔和徐佩玲提出了一种梅毒疫苗接种策略，其中可通过使用含有梅毒螺旋体抗原特定DNA序列的卡介苗载体疫苗来实现对DTH的选择性诱导。

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