Beem M O, Saxon E M
N Engl J Med. 1977 Feb 10;296(6):306-10. doi: 10.1056/NEJM197702102960604.
To learn if Chlamydia trachomatis causes in young infants a distinctive penumonia characterized by chronic, afebrile course, diffuse lung involvement and elevated serum immunoglobulins G and M, 47 black infants four to 24 weeks of age were examined for nasopharyngeal shedding of C. trachomatis and serum immunofluorescent antibody to lymphogranuloma venereum Type I. Nasopharyngeal C. trachomatis was found in 18 of 20 with the pneumonia syndrome, two of 15 with various other illnesses and 10 of 12 with inclusion conjunctivitis but without lower respiratory illness. Chlamydial antibody titers of infants with the pneumonia syndrome were significantly elevated (geometric mean-1, pneumonia vs. conjunctivitis = 24,833 vs. 1024 P less than 0.001). No other commonly recognized respiratory pathogens were consistently associated with the pneumonia syndrome. We believe these findings demonstrate an association between the distinctive pneumonia syndrome and C. trachomatis. This, in turn, is a particular facet of a more general event consisting of frequent colonization of the respiratory tract by C. trachomatis in natally acquired infection.
为了了解沙眼衣原体是否会在小婴儿中引起一种具有独特特征的肺炎，其特点为病程慢性、无发热、肺部弥漫性受累以及血清免疫球蛋白G和M升高，对47名年龄在4至24周的黑人婴儿进行了检查，检测其鼻咽部沙眼衣原体的排出情况以及针对I型性病性淋巴肉芽肿的血清免疫荧光抗体。在患有肺炎综合征的20名婴儿中，有18名检测到鼻咽部沙眼衣原体；在患有其他各种疾病的15名婴儿中，有2名检测到；在患有包涵体结膜炎但无下呼吸道疾病的12名婴儿中，有10名检测到。患有肺炎综合征的婴儿衣原体抗体滴度显著升高（几何平均数 - 肺炎组与结膜炎组分别为24,833和1024，P小于0.001）。没有其他常见的呼吸道病原体与该肺炎综合征始终相关。我们认为这些发现表明了这种独特的肺炎综合征与沙眼衣原体之间的关联。反过来，这又是一个更普遍事件的特定方面，该普遍事件包括在母婴传播感染中沙眼衣原体频繁定植于呼吸道。
