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Thrombin in inflammation and healing: relevance to rheumatoid arthritis.

作者信息

Morris R, Winyard P G, Blake D R, Morris C J

机构信息

Inflammation Research Group, London Hospital Medical College, United Kingdom.

出版信息

Ann Rheum Dis. 1994 Jan;53(1):72-9. doi: 10.1136/ard.53.1.72.

DOI:10.1136/ard.53.1.72
PMID:8311562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1005249/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/1005249/2760e0c2f0e6/annrheumd00489-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/1005249/6f3fd8a09624/annrheumd00489-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/1005249/2760e0c2f0e6/annrheumd00489-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/1005249/6f3fd8a09624/annrheumd00489-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95dc/1005249/2760e0c2f0e6/annrheumd00489-0083-a.jpg

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Thrombin in inflammation and healing: relevance to rheumatoid arthritis.炎症与愈合过程中的凝血酶：与类风湿关节炎的相关性
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[Physiopathologic mechanisms of synovium with rheumatoid arthritis].类风湿关节炎滑膜的病理生理机制
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Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis.树突状细胞在吸烟与类风湿性关节炎炎症之间提供了一个潜在的联系。
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Thrombin stimulates cell proliferation in human fibroblast-like synoviocytes in nuclear factor-kappaB activation and protein kinase C mediated pathway.凝血酶通过核因子-κB激活和蛋白激酶C介导的途径刺激人成纤维样滑膜细胞的细胞增殖。
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[Importance of the presence of iron in the subintimal synovial tissue in rheumatoid disease].
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What can we learn from the synovium in early rheumatoid arthritis?我们能从早期类风湿性关节炎的滑膜中学到什么？
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Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.血液凝固和炎症交汇点的病变：凝血酶在止血、癌症及其他方面的作用。

本文引用的文献

1
THE EFFECT OF EXPERIMENTAL HEMARTHROSIS ON ARTICULAR CARTILAGE OF RABBIT KNEE JOINTS.实验性关节积血对兔膝关节软骨的影响
J Bone Joint Surg Am. 1965 Sep;47:1203-10.
2
The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor.凝血酶在血管平滑肌细胞中的促有丝分裂作用很大程度上归因于碱性成纤维细胞生长因子。
J Biol Chem. 1993 Mar 15;268(8):5724-7.
3
Specific glycosaminoglycans support the inhibition of thrombin by plasminogen activator inhibitor 1.特定的糖胺聚糖可支持纤溶酶原激活物抑制剂1对凝血酶的抑制作用。
J Mol Med (Berl). 2013 Nov;91(11):1257-71. doi: 10.1007/s00109-013-1074-5. Epub 2013 Aug 17.
4
Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis.风湿性疾病中的凝血和纤维蛋白网络：超越止血作用的角色。
Nat Rev Rheumatol. 2012 Dec;8(12):738-46. doi: 10.1038/nrrheum.2012.184. Epub 2012 Nov 13.
5
Inhibition of antithrombin by hyaluronic acid may be involved in the pathogenesis of rheumatoid arthritis.透明质酸对抗凝血酶的抑制作用可能参与类风湿关节炎的发病机制。
Arthritis Res Ther. 2005;7(2):R268-73. doi: 10.1186/ar1487. Epub 2005 Jan 11.
6
Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets.蛋白酶激活受体1和4对人血小板中内皮抑素和血管内皮生长因子的释放起反向调节作用。
Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):216-20. doi: 10.1073/pnas.0406682102. Epub 2004 Dec 22.
7
Amelioration of collagen-induced arthritis by thrombin inhibition.通过抑制凝血酶改善胶原诱导的关节炎。
J Clin Invest. 2001 Mar;107(5):631-40. doi: 10.1172/JCI11064.
8
Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis.凝血酶抑制对抗原诱导性关节炎滑膜炎症的影响。
Ann Rheum Dis. 2000 Oct;59(10):781-7. doi: 10.1136/ard.59.10.781.
9
Prothrombin deficiency results in embryonic and neonatal lethality in mice.凝血酶原缺乏会导致小鼠胚胎和新生儿死亡。
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7597-602. doi: 10.1073/pnas.95.13.7597.
10
Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue.凝血酶受体在类风湿性和骨关节炎滑膜组织中的表达。
Ann Rheum Dis. 1996 Nov;55(11):841-3. doi: 10.1136/ard.55.11.841.
Biochemistry. 1993 Feb 16;32(6):1675-80. doi: 10.1021/bi00057a035.
4
Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors.
J Biol Chem. 1993 Feb 15;268(5):3720-7.
5
The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells: evidence for receptor hydrolysis in thrombin-dependent signalling.N 端凝血酶受体片段 SFLLRN 可激活 U937 人单核细胞，而催化失活的凝血酶衍生激动剂则不能：这是凝血酶依赖性信号传导中受体水解的证据。
Biochem J. 1993 Mar 1;290 ( Pt 2)(Pt 2):571-7. doi: 10.1042/bj2900571.
6
Glycosaminoglycans and the regulation of blood coagulation.糖胺聚糖与血液凝固的调节
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):313-30. doi: 10.1042/bj2890313.
7
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.凝血酶通过蛋白水解激活受体刺激培养的大鼠主动脉平滑肌细胞增殖。
J Clin Invest. 1993 Jan;91(1):94-8. doi: 10.1172/JCI116206.
8
Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions.慢性类风湿关节炎中的单核细胞-内皮细胞黏附。选择素和整合素依赖性相互作用的原位检测。
J Clin Invest. 1993 Jun;91(6):2609-19. doi: 10.1172/JCI116500.
9
Biologically active thrombomodulin is synthesized by adherent synovial fluid cells and is elevated in synovial fluid of patients with rheumatoid arthritis.生物活性血栓调节蛋白由黏附的滑液细胞合成，在类风湿关节炎患者的滑液中含量升高。
Blood. 1993 Feb 1;81(3):726-33.
10
DNA synthesis in human rheumatoid and nonrheumatoid synovial lining.人类类风湿性和非类风湿性滑膜衬里中的DNA合成。
Ann Rheum Dis. 1980 Jun;39(3):241-7. doi: 10.1136/ard.39.3.241.