Guo X B
Sanay Tropical Medicine Institute, Guangzhou College of Traditional Chinese Medicine.
Zhonghua Yi Xue Za Zhi. 1993 Oct;73(10):602-4, 638.
In 1988, 50 cases each of falciparum malaria were treated by dihydroartemisin (360 mg in 5 days and 480 mg in 7 days respectively), and compared randomly with piperaquine phosphate group. The results showed that the plasmodium of falciparal malaria in Dong Fang County, Hainan province, is much more resistant to piperaquine phosphate, in the 51 cases treated by piperaquine, 33.3% were sensitive, 19.0% were RI, 21.6% were RII, and 25.5% were RIII. The effect of dihydroartemisinin (both 5 days and 7 days therapy) were obviously better than that of pipera quine, fever subsidence time and parasite clearance time were similar and parasite recrudescence rate showed no obvious difference in these two groups too.
1988年，分别用双氢青蒿素（5天疗程360毫克、7天疗程480毫克）治疗恶性疟各50例，并与磷酸哌喹组进行随机对照。结果表明，海南省东方县恶性疟原虫对磷酸哌喹耐药性较强，在51例用磷酸哌喹治疗的患者中，敏感率为33.3%，RI为19.0%，RII为21.6%，RIII为25.5%。双氢青蒿素（5天和7天疗程）疗效明显优于磷酸哌喹，两组退热时间和原虫转阴时间相近，原虫复燃率也无明显差异。
