家族性阿尔茨海默病的连锁分析：杜克大学和波士顿数据集的描述

Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets.

作者信息

Pericak-Vance M A, St George-Hyslop P H, Gaskell P C, Growdon J, Crain B J, Hulette C, Gusella J F, Yamaoka L, Tanzi R E, Roses A D

机构信息

Division of Neurology, Duke University Medical Center, Durham, NC 27710.

出版信息

Genet Epidemiol. 1993;10(6):361-4. doi: 10.1002/gepi.1370100605.

DOI:10.1002/gepi.1370100605

PMID:8314027

Abstract

Familial Alzheimer diseases is a neurological disorder of adult onset. Three research centers have each contributed their families and genetic linkage data for combined analyses. The data from the Duke and Boston centers, comprising 73 pedigrees for whom numerous markers on chromosomes 19 and 21 were typed are described.

摘要

家族性阿尔茨海默病是一种成人起病的神经障碍。三个研究中心各自提供了他们的家系和基因连锁数据用于联合分析。描述了来自杜克大学和波士顿中心的数据，包括73个家系，对其19号和21号染色体上的众多标记进行了分型。