家族性阿尔茨海默病的双基因座模型？

A two-locus model for familial Alzheimer's disease?

作者信息

Macciardi F, Cavallini M C

机构信息

Istituto Scientifico H San Raffaele, Department of Neuroscience, University of Milano School of Medicine, Italy.

出版信息

Genet Epidemiol. 1993;10(6):437-41. doi: 10.1002/gepi.1370100618.

DOI:10.1002/gepi.1370100618

PMID:8314040

Abstract

The present findings for familial Alzheimer's disease suggest a possible linkage to gene(s) on chromosome 21 for the early onset form and to chromosome 19 for the late onset. Since these results are not unequivocal, possible alternative hypotheses include the effect of genetic heterogeneity or of an oligogenic model of segregation for FAD.

摘要

目前关于家族性阿尔茨海默病的研究结果表明，早发型可能与21号染色体上的基因存在联系，晚发型则与19号染色体相关。由于这些结果并不明确，其他可能的假说是遗传异质性的影响或家族性阿尔茨海默病的寡基因分离模型。