Gerber H R, Johansen S H, Mortimer J T, Yodlowski E
Anesthesiology. 1977 Jan;46(1):35-9. doi: 10.1097/00000542-197701000-00008.
A new method for monitoring the effect of muscle relaxants on the myoneural junction was tested in unanesthetized volunteers. Evoked electromyographic responses to stimulation, sweeping exponentially from 1 to 100 Hz over 10 seconds, were recorded from the hand and abdominal muscles. d-Tubocurarine (dTc) was given intravenously in incremental doses until head lift was abolished. Thumb twitch tension, vital capacity, peak expiratory flow, maximal inspiratory force, and hand grip strength were recorded during partial paralysis and recovery. The frequency sweep electromyogram (FS-EMG) of the musculus rectus abdominis was more depressed than the FS-EMG of the musculus abductor digiti V at the time head lift was abolished. The abdominal muscle recovered faster from dTc paralysis than did the hand muscle. The latter failed to respond normally to the highest frequencies of stimulation during the entire period of observation lasting 72 minutes after dTc injection. At the time of maximal neuromuscular blockade, respiratory function showed less depression than the FS-EMG of the abdominal muscle.
在未麻醉的志愿者身上测试了一种监测肌肉松弛剂对肌神经接头作用效果的新方法。从手部和腹部肌肉记录对刺激的诱发肌电图反应，刺激频率在10秒内从1赫兹呈指数级扫频至100赫兹。静脉内递增剂量给予d -筒箭毒碱（dTc），直至抬头动作消失。在部分麻痹和恢复过程中记录拇指抽搐张力、肺活量、呼气峰值流速、最大吸气力和握力。在抬头动作消失时，腹直肌的频率扫频肌电图（FS - EMG）比小指展肌的FS - EMG受到的抑制更明显。腹部肌肉从dTc麻痹中恢复得比手部肌肉更快。在dTc注射后持续72分钟的整个观察期间，手部肌肉对最高频率刺激未能正常反应。在最大神经肌肉阻滞时，呼吸功能的抑制程度比腹部肌肉的FS - EMG轻。
