焦化厂中致癌物暴露与癌症风险的生物标志物。
Biomarkers of carcinogen exposure and cancer risk in a coke plant.
作者信息
Assennato G, Ferri G M, Tockman M S, Poirier M C, Schoket B, Porro A, Corrado V, Strickland P T
机构信息
Istituto di Medicina del Lavoro, Università degli Studi di Bari, Italy.
出版信息
Environ Health Perspect. 1993 Mar;99:237-9. doi: 10.1289/ehp.9399237.
To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic transformation (sputum epithelial cell membrane antigens binding by monoclonal antibodies against small cell lung cancer and against nonsmall cell lung cancer), a survey of 350 coke-oven workers and 100 unexposed workers was planned. This paper reports a pilot investigation on a subgroup of 23 coke-oven workers and 8 unexposed controls. A "gas regulator" worker with positive tumor antigen binding was identified. Results show that smokers, subjects with decreased pulmonary function (forced expiratory volume in 1 sec/forced vital capacity% < 80), and those with morphological dysplasia of sputum cells have higher levels of DNA adducts. The gas regulators showed the highest values for adducts; however, no significant difference of adduct levels was found between the coke-oven group and unexposed controls.
为了评估致癌物暴露指标（多环芳烃的外周血白细胞DNA加合物）与肿瘤转化早期指标（针对小细胞肺癌和非小细胞肺癌的单克隆抗体结合的痰上皮细胞膜抗原）之间的关联，计划对350名焦炉工人和100名未暴露工人进行调查。本文报告了对23名焦炉工人和8名未暴露对照组成的亚组进行的初步调查。识别出一名肿瘤抗原结合呈阳性的“气体调节工”。结果显示，吸烟者、肺功能下降者（1秒用力呼气量/用力肺活量%<80）以及痰细胞形态发育异常者的DNA加合物水平较高。气体调节工的加合物值最高；然而，焦炉组与未暴露对照组之间的加合物水平没有显著差异。
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