胶质瘤患者脑脊液中转化生长因子-β活性形式的检测
Detection of active form of transforming growth factor-beta in cerebrospinal fluid of patients with glioma.
作者信息
Tada T, Yabu K, Kobayashi S
机构信息
Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto.
出版信息
Jpn J Cancer Res. 1993 May;84(5):544-8. doi: 10.1111/j.1349-7006.1993.tb00174.x.
Abstract
We examined transforming growth factor-beta (TGF-beta) activity in cerebrospinal fluid of 39 patients with various brain tumors, and found it in 10 glioma cases that had lesions related to subarachnoid space or ventricle. In one glioma case, TGF-beta detected on admission disappeared after radiation and chemotherapy. We confirmed that five glioma cell lines produced TGF-beta, and that four of them produced active form of TGF-beta directly. The active form of TGF-beta was also identified from cerebrospinal fluid before the acidification treatment in two cases. The calculated contents were 110 ng/ml and 18 ng/ml. These results indicate that active form of TGF-beta is directly produced by tumor cells in patients with glioma, and may contribute to immunodeficiency of the host.
摘要
我们检测了39例患有各种脑肿瘤患者脑脊液中的转化生长因子-β（TGF-β）活性，在10例与蛛网膜下腔或脑室相关病变的胶质瘤病例中检测到了该因子。在1例胶质瘤病例中，入院时检测到的TGF-β在放疗和化疗后消失。我们证实5种胶质瘤细胞系产生TGF-β，其中4种直接产生活性形式的TGF-β。在2例病例中，酸化处理前的脑脊液中也鉴定出了活性形式的TGF-β。计算含量分别为110 ng/ml和18 ng/ml。这些结果表明，胶质瘤患者肿瘤细胞直接产生活性形式的TGF-β，这可能导致宿主免疫缺陷。
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