溴与甲状腺激素活性。
Bromine and thyroid hormone activity.
作者信息
Allain P, Berre S, Krari N, Laine P, Barbot N, Rohmer V, Bigorgne J C
机构信息
Laboratoire de Pharmacologie, Centre Hospitalier Universitaire, Angers, France.
出版信息
J Clin Pathol. 1993 May;46(5):456-8. doi: 10.1136/jcp.46.5.456.
AIMS
To examine the possible consequences of high plasma concentrations of bromine on thyroid hormone.
METHODS
Bromine was measured by inductively coupled plasma mass spectrometry in the plasma of 799 patients consulting for thyroid disorders. Because the mean (SD) bromine concentration in the plasma of healthy subjects is 4 (1) mg/l, concentrations above 6 mg/l were regarded as outside the normal range. Bromine, free thyroxine (FT4), and thyroid stimulating hormone (TSH) values were compared.
RESULTS
The percentage of patients with normal, low, and high FT4 and TSH plasma activities, measured separately, did not differ between patients with low and high bromine concentrations. The percentage of patients with high TSH but normal FT4 values was significantly higher in the group with bromine values of more than 6 mg/l than in the group with bromine concentrations below this (p < 0.02).
CONCLUSION
An increase in plasma bromine could potentiate an increase in plasma TSH concentration, probably as a consequence of a minor inhibitory effect on thyroid activity.
目的
研究高血浆溴浓度对甲状腺激素可能产生的影响。
方法
采用电感耦合等离子体质谱法测定799例因甲状腺疾病前来咨询的患者血浆中的溴含量。由于健康受试者血浆中溴浓度的均值（标准差）为4（1）mg/l，所以血浆溴浓度高于6mg/l被视为超出正常范围。对溴、游离甲状腺素（FT4）和促甲状腺激素（TSH）的值进行了比较。
结果
血浆溴浓度低和高的患者之间，单独测量的FT4和TSH血浆活性正常、低和高的患者百分比无差异。溴值高于6mg/l的组中TSH高但FT4值正常的患者百分比显著高于溴浓度低于此值的组（p<0.02）。
结论
血浆溴的增加可能会增强血浆TSH浓度的升高，这可能是对甲状腺活动产生轻微抑制作用的结果。
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