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Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth.

作者信息

Rouzaire-Dubois B, Gérard V, Dubois J M

机构信息

Laboratoire de Physiologie Cellulaire, URA CNRS 1121, Orsay, France.

出版信息

Pflugers Arch. 1993 May;423(3-4):202-5. doi: 10.1007/BF00374395.

DOI:10.1007/BF00374395
PMID:8321622
Abstract

The effects of the flavonoid quercetin on cell proliferation and voltage-dependent K+ current were studied on mouse neuroblastoma x glioma hybrid cells. In the presence of 1% fetal calf serum, quercetin inhibited both cell proliferation and K+ current with effective doses inducing half-maximum effects of 10 microM and 70 microM respectively. Valinomycin (1 nM) antagonized 80% of the growth-inhibitory effects of 10 microM quercetin. The results suggest that at least a part of the anti-proliferative effect of quercetin is mediated by a K+ channel blockade. They further confirm a role for K+ channels in mitogenesis and cell proliferation.

摘要

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本文引用的文献

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Role of potassium channels in mitogenesis.钾通道在有丝分裂原作用中的角色。
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Triggering of lymphocyte capping appears not to require changes in potential or ion fluxes across the plasma membrane.淋巴细胞帽状形成的触发似乎并不需要跨质膜的电位或离子通量发生变化。
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Involvement of PACAP/ADNP signaling in the resistance to cell death in malignant peripheral nerve sheath tumor (MPNST) cells.PACAP/ADNP 信号转导在恶性外周神经鞘瘤（MPNST）细胞抵抗细胞死亡中的作用。
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Inhibition of 7,12-dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin.膳食黄酮醇槲皮素对7,12-二甲基苯并(a)蒽和N-亚硝基甲基脲诱导的大鼠乳腺癌的抑制作用。
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Voltage- and calcium-activated potassium currents in mouse neuroblastoma x rat glioma hybrid cells.小鼠神经母细胞瘤×大鼠胶质瘤杂交细胞中的电压门控性和钙激活钾电流
J Physiol. 1988 Mar;397:149-65. doi: 10.1113/jphysiol.1988.sp016993.
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Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels.离子通道阻滞剂在细胞周期G1期的精确阶段抑制B细胞活化。钾离子通道可能参与其中。
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Tamoxifen blocks both proliferation and voltage-dependent K+ channels of neuroblastoma cells.他莫昔芬可阻断神经母细胞瘤细胞的增殖和电压依赖性钾通道。
Cell Signal. 1990;2(4):387-93. doi: 10.1016/0898-6568(90)90069-m.
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Modification of electrophysiological and pharmacological properties of K channels in neuroblastoma cells induced by the oxidant chloramine-T.
Pflugers Arch. 1990 Jun;416(4):393-7. doi: 10.1007/BF00370745.
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Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.槲皮素和芦丁作为乙氧甲基甲醇诱导的结肠肿瘤形成的抑制剂。
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