Thomas D J, Young A, Gorsuch A N, Bottazzo G F, Cudworth A G
Ann Rheum Dis. 1983 Jun;42(3):297-300. doi: 10.1136/ard.42.3.297.
Evidence is presented for the first time of a significantly increased prevalence of type 1 (insulin-dependent) diabetes in the close relatives of patients with rheumatoid arthritis. Thirty-nine (13%) of 295 patients with classical or definite rheumatoid arthritis had a first or second degree relative with type 1 diabetes and 38 (13%) had a close relative with autoimmune thyroid disease. These findings could be compatible with a possible common genetically determined mechanism of susceptibility to both diseases.
首次有证据表明,类风湿关节炎患者的近亲中1型(胰岛素依赖型)糖尿病的患病率显著增加。295例典型或确诊类风湿关节炎患者中,39例(13%)有一级或二级亲属患1型糖尿病,38例(13%)有近亲患自身免疫性甲状腺疾病。这些发现可能与两种疾病共同的遗传易感性机制相符。