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自然和非自然原因导致的高死亡率:对自杀未遂后入住中毒治疗中心的患者进行的10年随访研究

High mortality by natural and unnatural causes: a 10 year follow up study of patients admitted to a poisoning treatment centre after suicide attempts.

作者信息

Nordentoft M, Breum L, Munck L K, Nordestgaard A G, Hunding A, Laursen Bjaeldager P A

机构信息

Psychiatric Department, Bispebjerg Hospital, University of Copenhagen, Denmark.

出版信息

BMJ. 1993 Jun 19;306(6893):1637-41. doi: 10.1136/bmj.306.6893.1637.

Abstract

OBJECTIVE

To describe mortality by suicide and other causes of death in a group of patients who attempted suicide, and to identify predictive factors.

DESIGN

10 year follow up study based on records of suicide attempters in 1980.

SETTING

Poisoning treatment centre at a general hospital.

SUBJECTS

974 patients aged 15 and over referred to the poisoning treatment centre after deliberate self poisoning.

MAIN OUTCOME MEASURES

Death by different causes registered in the Danish death cause register.

RESULTS

In 10 years of follow up 306 patients died: 103 by suicide, 131 from natural causes, and 31 by accident; five were murdered, and in 36 cases the cause of death was uncertain. The standard mortality ratio was 550. Cause specific standardised mortality rates were 2960 for suicide, 236 for natural causes, 1256 for accidents, and 5459 for uncertain causes. In a Cox regression analysis, high risk factors for subsequent suicide were: more than one previous suicide attempt (relative risk 2.25), living alone (2.28), and age (1.03 per year). Predictors of death by natural causes were receiving a pension (1.69), drug misuse (2.72), more than one previous suicide attempt (2.25), age (1.06 per year), and male sex (2.49). The group of patients fulfilling at least one high risk criterion for later suicide differed significantly from the rest of the patient group in incidence of suicide, but both sensitivity and specificity were low.

CONCLUSIONS

Most patients who attempted suicide were at high risk of succeeding because the risk factors, though significant, are not very specific. A strategy to prevent suicide must be directed toward the majority of those who attempt suicide.

摘要

目的

描述一组自杀未遂患者的自杀及其他死因死亡率,并确定预测因素。

设计

基于1980年自杀未遂者记录的10年随访研究。

地点

一家综合医院的中毒治疗中心。

研究对象

974名15岁及以上因故意自服中毒被转诊至中毒治疗中心的患者。

主要观察指标

丹麦死因登记册中登记的不同原因导致的死亡。

结果

在10年的随访中,306名患者死亡:103人自杀死亡,131人自然死亡,31人意外死亡;5人被谋杀,36例死因不明。标准死亡率为550。特定原因的标准化死亡率分别为:自杀2960、自然原因236、意外1256、不明原因5459。在Cox回归分析中,后续自杀的高危因素为:既往有一次以上自杀未遂(相对风险2.25)、独居(2.28)和年龄(每年1.03)。自然死亡的预测因素为领取养老金(1.69)、药物滥用(2.72)、既往有一次以上自杀未遂(2.25)、年龄(每年1.06)和男性(2.49)。满足至少一项后续自杀高危标准的患者组与其他患者组在自杀发生率上有显著差异,但敏感性和特异性均较低。

结论

大多数自杀未遂患者成功自杀的风险较高,因为这些危险因素虽然显著,但特异性不强。预防自杀的策略必须针对大多数自杀未遂者。

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