Elder M G, Myatt L, Chaudhuri G
Fertil Steril. 1977 Jan;28(1):86-90. doi: 10.1016/s0015-0282(16)42322-8.
Spontaneous isometric contractions of the human fallopian tube were measured in vitro. The tubes were obtained during the follicular phase of the menstrual cycle in 16 experiments and during the luteal phase in 23 experiments. The area under the curve and the frequency of spontaneous isometric contractions, together with the amount of prostaglandins E and F produced by the tube, were measured. Using each tissue as its own control, the effects of adding indomethacin or papeverine to the tissue both were assessed. Indomethacin, a prostaglandin synthetase inhibitor, significantly reduced the prostaglandin output without affecting the tubal motility. By contrast, papaverine, which is a smooth muscle relaxant but not an inhibitor of prostaglandin synthesis, significantly reduced both motility and prostaglandin output. It is concluded that prostaglandins do not have a direct role in the regulation of the spontaneous motility of the human fallopian tube.
在体外测量了人体输卵管的自发性等长收缩。在16次实验中，输卵管取自月经周期的卵泡期，在23次实验中取自黄体期。测量了曲线下面积和自发性等长收缩频率，以及输卵管产生的前列腺素E和F的量。以每个组织自身作为对照，评估了向组织中添加吲哚美辛或罂粟碱的效果。吲哚美辛是一种前列腺素合成酶抑制剂，可显著降低前列腺素的产生量，而不影响输卵管的运动性。相比之下，罂粟碱是一种平滑肌松弛剂，但不是前列腺素合成抑制剂，可显著降低运动性和前列腺素的产生量。得出的结论是，前列腺素在人体输卵管自发性运动的调节中没有直接作用。
