Beauchamp G K, Fisher A S
Monell Chemical Senses Center, Philadelphia, PA 19104-3308.
Physiol Behav. 1993 Jul;54(1):179-84. doi: 10.1016/0031-9384(93)90063-l.
Intake of saline (NaCl) solutions and water by males of two inbred strains of mice [C57BL/6J (C57) and 129/J] were examined using 48-h, two-bottle preference tests. There was a large strain difference in saline intake: at moderate concentrations (0.075-0.150 M) C57 mice tended to reject saline relative to water, whereas 129/J mice preferred it. Both strains of mice increased their intake of saline following lasix-induced sodium depletion and the preference exhibited by 129/J mice for 0.15 M NaCl was eliminated following LiCl toxicosis. The rejection of moderate concentrations of saline by C57 was shown to be due, in part at least, to prior exposure to iso- or hypertonic saline solutions: C57 mice that had no prior exposure to saline exhibited a greater intake of saline than C57 mice previously exposed to 0.30 M NaCl. Saline preferences of the 129/J mice were not affected by prior exposure to 0.30 M NaCl. Thus, the strain difference in mouse salt preference is due in part to postingestional consequences of saline consumption in C57 but not 129/J mice.
采用48小时双瓶偏好试验，对两种近交系雄性小鼠[C57BL/6J（C57）和129/J]的生理盐水（NaCl）溶液和水摄入量进行了检测。生理盐水摄入量存在很大的品系差异：在中等浓度（0.075 - 0.150 M）下，相对于水，C57小鼠倾向于拒绝生理盐水，而129/J小鼠则更喜欢它。两种品系的小鼠在速尿诱导的钠耗竭后，生理盐水摄入量均增加，并且在氯化锂中毒后，129/J小鼠对0.15 M NaCl的偏好消失。结果表明，C57小鼠对中等浓度生理盐水的拒绝至少部分是由于先前接触过等渗或高渗盐溶液：未接触过生理盐水的C57小鼠比先前接触过0.30 M NaCl的C57小鼠摄入更多的生理盐水。先前接触0.30 M NaCl对129/J小鼠的生理盐水偏好没有影响。因此，小鼠盐偏好的品系差异部分归因于C57小鼠而非129/J小鼠摄入生理盐水后的消化后效应。
