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Gamma irradiation increases hsp-70 in Chinese hamster ovary cells.

作者信息

Sierra-Rivera E, Voorhees G J, Freeman M L

机构信息

Vanderbilt Center for Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.

出版信息

Radiat Res. 1993 Jul;135(1):40-5. doi: 10.2307/3578394.

DOI:10.2307/3578394
PMID:8327659
Abstract

The induction of hsp-70 by gamma irradiation was studied in Chinese hamster ovary (CHO) cells. Synthesis of hsp-70 was assessed by SDS-PAGE of radiolabeled proteins while levels of hsp-70 mRNA were estimated by Northern blot analysis of total RNA. SDS-PAGE analysis indicated that the synthesis of hsp-70 was enhanced in cells exposed to 400 or 1000 Gy. Northern blot analysis of RNA from cells exposed to 1000 Gy indicated a rapid increase in mRNA capable of hybridizing to an hsp-70 oligonucleotide probe. These experiments represent the first report demonstrating that ionizing radiation can increase hsp-70 mRNA.

摘要

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