Snape W J, Carlson G M, Matarazzo S A, Cohen S
Gastroenterology. 1977 Mar;72(3):383-7.
Although the irritable bowel syndrome is characterized as an abnormality in colonic motor activity occurring in response to certain stimuli, the etiology of this disorder is unclear. The purpose of this study is to determine the relationship of altered slow wave activity and the abnormal motility of the distal colon seen in patients with the irritable bowel syndrome. Myoelectrical activity was recorded using a bipolar electrode clipped to the distal colonic mucosa and motor activity was measured by perfused catheters. Colonic slow waves and contractions were present at two frequencies, 6 and 3 cycles per min. The slow wave frequency seemed to determine the frequency of colonic motor activity. Patients with the irritable bowel syndrome had increased 3-cycle per min slow wave activity in the basal state (P less than 0.001). However, no difference in basal 3-cycle per min motor activity was present between the two groups (P greater than 0.05). When colonic motor activity was increased with cholecystokinin or pentagastrin, patients with irritable bowel syndrome showed a marked increase in 3-cycle per min contractile activity, occurring simultaneously with 3-cycle per min slow wave activity. These studies suggest that increased colonic 3-cycle per min slow wave activity in patients with the irritable bowel syndrome may be the basic abnormality that leads to colonic motor dysfunction in response to various physiological stimuli.
虽然肠易激综合征的特征是结肠运动活动异常，这种异常是对某些刺激的反应，但该疾病的病因尚不清楚。本研究的目的是确定肠易激综合征患者中慢波活动改变与远端结肠异常运动之间的关系。使用夹在远端结肠黏膜上的双极电极记录肌电活动，并通过灌注导管测量运动活动。结肠慢波和收缩以每分钟6次和3次的频率出现。慢波频率似乎决定了结肠运动活动的频率。肠易激综合征患者在基础状态下每分钟3次的慢波活动增加（P<0.001）。然而，两组之间每分钟3次的基础运动活动没有差异（P>0.05）。当用胆囊收缩素或五肽胃泌素增加结肠运动活动时，肠易激综合征患者每分钟3次的收缩活动显著增加，同时伴有每分钟3次的慢波活动。这些研究表明，肠易激综合征患者每分钟3次的结肠慢波活动增加可能是导致结肠对各种生理刺激产生运动功能障碍的基本异常。
