Förster H, Boecker S, Walther A
Fortschr Med. 1977 Jan 13;95(2):99-102.
In 24 diabetic children treated with insulin xylitol was used as a sugar substitute for four weeks in an amount of 30 gms/day. In one case only the xylitol application was terminated before the end of the dietetic period because of diarrhoea. The other children tolerated xylitol fairly well, three of the children found the polyol too sweet. Because of incomplete data, the values of only 18 children were compiled. A significant increase of serum uric acid concentration measuring 1 mg/100 ml was the main side effect of xylitol usage. This effect was favoured by the fact that diabetic children do not use sucrose. As was shown earlier, a sucrose free period is the precondition for the possibility to find a xylitol induced hyperuricemia. In metabolically healthy children the existence of a sucrose induced hyperuricemia is also to be expected, this xylitol effect is, therefore, obviously without pathophysiological significance. Xylitol is suited for use as a sugar substitute in diabetic diet and in caries prophylaxis if the limited dose is observed.
在24名接受胰岛素治疗的糖尿病儿童中，木糖醇被用作糖替代品，为期四周，用量为每日30克。仅1例因腹泻在饮食期结束前终止了木糖醇的使用。其他儿童对木糖醇耐受性相当好，3名儿童觉得该多元醇太甜。由于数据不完整，仅汇总了18名儿童的值。使用木糖醇的主要副作用是血清尿酸浓度显著升高，测量值为1毫克/100毫升。糖尿病儿童不使用蔗糖这一事实促成了这种效应。如先前所示，无糖期是发现木糖醇诱发高尿酸血症可能性的前提条件。在代谢健康的儿童中也可预期存在蔗糖诱发的高尿酸血症，因此，这种木糖醇效应显然没有病理生理学意义。如果遵守限定剂量，木糖醇适合在糖尿病饮食和预防龋齿中用作糖替代品。
