Zabinski R A, Larsson A J, Walker K J, Gilliland S S, Rotschafer J C
Miles Inc., West Haven, Connecticut 06516-4175.
Antimicrob Agents Chemother. 1993 Jun;37(6):1377-9. doi: 10.1128/AAC.37.6.1377.
To prove the utility of antibiotic-removal beads in separating antibiotics from bacterial samples, Escherichia coli ATCC 25922 was exposed to five separate quinolones before and after each was exposed to antibiotic-removal beads. Plates treated with antibiotic solutions that were exposed to beads demonstrated antibiotic removal, and plates treated with antibiotic solutions that were not exposed to beads demonstrated antibiotic carryover. After exposure to beads, fluoroquinolone concentrations decreased from 5 micrograms/ml to 0.14 micrograms/ml (ciprofloxacin), 0.04 micrograms/ml (temafloxacin), < 0.01 microgram/ml (ofloxacin), < 0.01 microgram/ml (sparfloxacin), and 0.02 micrograms/ml (clinafloxacin). These data indicate that antibiotic carryover can be successfully circumvented through the use of antibiotic-removal beads.
为证明抗生素去除珠在从细菌样本中分离抗生素方面的效用，在将大肠埃希菌ATCC 25922分别暴露于五种喹诺酮类药物前后，均使其接触抗生素去除珠。用接触过珠子的抗生素溶液处理的平板显示抗生素被去除，而用未接触珠子的抗生素溶液处理的平板显示有抗生素残留。接触珠子后，氟喹诺酮类药物浓度从5微克/毫升降至0.14微克/毫升（环丙沙星）、0.04微克/毫升（替马沙星）、<0.01微克/毫升（氧氟沙星）、<0.01微克/毫升（司帕沙星）和0.02微克/毫升（克林沙星）。这些数据表明，通过使用抗生素去除珠可成功避免抗生素残留。
