Krol W, Scheller S, Shani J, Pietsz G, Czuba Z
Department of Microbiology and Immunology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
Arzneimittelforschung. 1993 May;43(5):607-9.
Ethanolic extract of propolis (EEP), known to possess marked antibacterial activity, was incubated with 8 different common antibiotics in culture medium containing a fixed amount of a standard strain of Staphylococcus aureus. The antibiotic compounds used were: penicillin G, doxycycline, streptomycin, cloxacillin, chloramphenicol, cefradine, ampicillin and polymyxin B. They were used in varying levels, ranging between 0.000005-125.0 micrograms/ml or units, resp. Firstly, their minimal inhibitory concentrations were established in the absence of EEP, than EEP was added in concentrations up to 600 micrograms/ml. EEP had a marked synergistic effect on the antibacterial activity of streptomycin and cloxacillin, and a moderate synergistic effect on the others, except ampicillin.
已知具有显著抗菌活性的蜂胶乙醇提取物（EEP），在含有固定量金黄色葡萄球菌标准菌株的培养基中与8种不同的常见抗生素一起培养。所使用的抗生素化合物为：青霉素G、强力霉素、链霉素、氯唑西林、氯霉素、头孢拉定、氨苄青霉素和多粘菌素B。它们以不同水平使用，分别在0.000005 - 125.0微克/毫升或单位之间。首先，在不存在EEP的情况下确定它们的最低抑菌浓度，然后添加浓度高达600微克/毫升的EEP。EEP对链霉素和氯唑西林的抗菌活性有显著协同作用，对其他抗生素（氨苄青霉素除外）有中等协同作用。
