Oxenhandler R W, Adelstein E H, Rogers W A
J Clin Microbiol. 1977 Jan;5(1):31-3. doi: 10.1128/jcm.5.1.31-33.1977.
Ten of thirteen patients with positive histolatex agglutination titers of 1:32 or greater had no evidence of acute histoplasmosis. Three of these false positives had rheumatoid arthritis. A fourth had a rising mycoplasma complement fixation titer, and the fifth had a high titer of cold agglutinins. All of these are associated with abnormal immunoglobulin M production. To evaluate the role of rheumatoid factor in producing false positive histolatex agglutination, the histolatex test was performed on sera from 32 patients having rheumatoid factor at a titer of 1:40 or greater. Four of these sera agglutinated the histoplasmin-coated latex particles at titers of 1:32 or greater. Review of clinical records suggests the this reactivity is nonspecific. It is our purpose to call attention to rheumatoic factor as a cause of false positive histolatex agglutination.
13例组织胞浆菌素凝集试验滴度为1:32或更高且结果呈阳性的患者中，有10例没有急性组织胞浆菌病的证据。这些假阳性患者中有3例患有类风湿性关节炎。第4例患者支原体补体结合试验滴度升高，第5例患者冷凝集素滴度较高。所有这些都与免疫球蛋白M产生异常有关。为了评估类风湿因子在产生组织胞浆菌素凝集试验假阳性中的作用，对32例类风湿因子滴度为1:40或更高的患者的血清进行了组织胞浆菌素试验。其中4份血清以1:32或更高的滴度凝集了包被组织胞浆菌素的乳胶颗粒。临床记录回顾表明这种反应是非特异性的。我们的目的是提醒人们注意类风湿因子是组织胞浆菌素凝集试验假阳性的一个原因。
