白细胞介素-8增强人粒细胞对偶然分枝杆菌的非氧化细胞内杀伤作用。
Interleukin-8 enhances nonoxidative intracellular killing of Mycobacterium fortuitum by human granulocytes.
作者信息
Nibbering P H, Pos O, Stevenhagen A, Van Furth R
机构信息
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
出版信息
Infect Immun. 1993 Aug;61(8):3111-6. doi: 10.1128/iai.61.8.3111-3116.1993.
Abstract
The results of this study show that recombinant interleukin-8 (IL-8) enhances the intracellular killing of Mycobacterium fortuitum by human granulocytes. This chemokine did not stimulate the phagocytosis of M. fortuitum by granulocytes at various bacterium-to-cell ratios. The killing process was not affected by the NADPH oxidase inhibitor diphenyleneiodonium bisulfate, which indicates that recombinant IL-8 stimulates oxygen-independent mycobactericidal mechanisms of granulocytes. IL-8 did not stimulate H2O2 production in granulocytes but primed the cells for enhanced H2O2 production upon stimulation with preopsonized M. fortuitum. In sum, the chemokine IL-8 not only is involved in the recruitment of granulocytes to the site of infection but also facilitates the elimination of microorganisms by increasing the efficiency of the bactericidal activity of granulocytes.
摘要
本研究结果表明，重组白细胞介素-8（IL-8）可增强人粒细胞对偶然分枝杆菌的胞内杀伤作用。在不同细菌与细胞比例下，这种趋化因子不会刺激粒细胞对偶然分枝杆菌的吞噬作用。杀伤过程不受NADPH氧化酶抑制剂二苯碘鎓双硫酸盐的影响，这表明重组IL-8刺激粒细胞的非氧依赖性杀分枝杆菌机制。IL-8不会刺激粒细胞产生过氧化氢，但在用经调理的偶然分枝杆菌刺激时，会使细胞做好增强过氧化氢产生的准备。总之，趋化因子IL-8不仅参与粒细胞向感染部位的募集，还通过提高粒细胞杀菌活性的效率来促进微生物的清除。
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