Pienta K J, Lehr J E
Meyer L. Prentis Comprehensive Cancer Center, Wayne State University School of Medicine, Detroit, Michigan.
Prostate. 1993;23(1):61-7. doi: 10.1002/pros.2990230106.
The nuclear matrix is the RNA-protein network which forms the skeleton of the nucleus, and participates in DNA organization as well as in multiple cellular functions. Nuclear matrix proteins have been demonstrated to be tissue and cell type specific, as well as to reflect the state of cell differentiation and/or transformation. Previously, common nuclear matrix proteins were demonstrated between the rat prostate and the Dunning rat prostate adenocarcinoma cell lines. This study demonstrates that nuclear matrices derived from Dunning rat and human prostate cancer cell lines, as well as human tumors, share several common proteins. These common proteins suggest that alterations which occur in the nuclear matrix with prostate cell transformation may share a common basis.
核基质是形成细胞核骨架的RNA-蛋白质网络，参与DNA组织以及多种细胞功能。核基质蛋白已被证明具有组织和细胞类型特异性，并且能够反映细胞分化和/或转化的状态。先前已证明大鼠前列腺和邓宁大鼠前列腺腺癌细胞系之间存在常见的核基质蛋白。本研究表明，源自邓宁大鼠和人类前列腺癌细胞系以及人类肿瘤的核基质具有几种共同的蛋白质。这些共同的蛋白质表明，前列腺细胞转化时核基质中发生的改变可能有共同的基础。
