Seiberth V, Schatanek S, Alexandridis E
Universitäts-Augenklinik, Heidelberg, Germany.
Graefes Arch Clin Exp Ophthalmol. 1993 Jun;231(6):318-22. doi: 10.1007/BF00919027.
The range of wavelengths used in ophthalmic photocoagulation treatment has been greatly enlarged by the development of the dye laser. To investigate the efficacy and possible side effects of orange dye laser light in the treatment of diabetic retinopathy, we performed a prospective, controlled clinical study comparing argon blue-green and orange dye laser light. In 14 patients with diabetic retinopathy of equal severity in both eyes one eye was randomly assigned to either blue-green argon (488 and 514.5 nm) or orange dye (600 nm) panretinal laser treatment. The total coagulated area was the same in both eyes. Subjective parameters (visual acuity, perimetry, color vision) as well as objective functions (electroretinography, electro-oculography) and the clinical course were studied preoperatively and then postoperatively over a period of 6 months. Dye laser coagulation proved as effective and safe as blue-green argon laser coagulation in the panretinal treatment of diabetic retinopathy. No significant differences in postoperative retinal function were detected. However, orange laser coagulation proved significantly more painful than blue-green argon laser treatment (P = 0.002).
染料激光的发展极大地拓宽了眼科光凝治疗中所使用的波长范围。为了研究橙色染料激光治疗糖尿病性视网膜病变的疗效及可能的副作用，我们进行了一项前瞻性对照临床研究，比较氩蓝绿激光和橙色染料激光。在14例双眼糖尿病性视网膜病变严重程度相同的患者中，随机将一只眼分配接受蓝绿氩激光（488和514.5纳米）或橙色染料激光（600纳米）全视网膜激光治疗。双眼的总凝固面积相同。术前及术后6个月期间，研究主观参数（视力、视野、色觉）以及客观功能（视网膜电图、眼电图）和临床病程。在糖尿病性视网膜病变的全视网膜治疗中，染料激光凝固与蓝绿氩激光凝固一样有效且安全。术后视网膜功能未检测到显著差异。然而，橙色激光凝固比蓝绿氩激光治疗明显更痛（P = 0.002）。
