Seiberth V, Alexandridis E, Feng W
Department of Clinical and Experimental Ophthalmology, University Eye Clinic, Heidelberg, Federal Republic of Germany.
Graefes Arch Clin Exp Ophthalmol. 1987;225(6):385-90. doi: 10.1007/BF02334163.
Panretinal photocoagulation has been demonstrated to have a beneficial effect on the natural history of diabetic retinopathy. However, it is associated with detectable loss of retinal function. To determine the best coagulation technique we conducted a prospective study in 32 eyes of 16 patients. We investigated retinal function in relation to spot size and scatter density after panretinal laser coagulation. One eye was treated with approximately 400 comparatively large laser spots (0.6-0.8 mm diameter), whereas the fellow eye was coagulated with approximately 1500 small spots (0.2-0.4 mm diameter), so that the total coagulated area was almost the same in both eyes. Subjective parameters (visual acuity, perimetry, dark adaptation, photostress), as well as objective functions (electroretinogram, ERG; electro-oculogram, EOG), were studied preoperatively and then postoperatively over a time span of 6 months. Pronounced impairment of retinal function was detected, which recovered after 3 months on the average. When the pairs of eyes were compared, persistent visual field scotomas as detected by computerized static perimetry, occurred less frequently in eyes subjected to small coagulation spots, although this tendency was not statistically significant.
全视网膜光凝已被证明对糖尿病视网膜病变的自然病程有有益作用。然而，它与可检测到的视网膜功能丧失有关。为了确定最佳的光凝技术，我们对16例患者的32只眼睛进行了一项前瞻性研究。我们研究了全视网膜激光光凝后视网膜功能与光斑大小和散射密度的关系。一只眼睛用大约400个相对较大的激光光斑（直径0.6 - 0.8毫米）进行治疗，而另一只眼睛用大约1500个小光斑（直径0.2 - 0.4毫米）进行光凝，以使两只眼睛的总光凝面积几乎相同。术前以及术后6个月内研究主观参数（视力、视野检查、暗适应、光应激）以及客观功能（视网膜电图，ERG；眼电图，EOG）。检测到视网膜功能有明显损害，平均3个月后恢复。当比较双眼时，通过计算机静态视野检查检测到的持续性视野暗点在接受小光凝光斑治疗的眼睛中出现频率较低，尽管这种趋势没有统计学意义。
