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[血清学在热带念珠菌败血症诊断中的应用价值]

[Usefulness of serology in the diagnosis of Candida tropicalis septicemia].

作者信息

Quindós G, Reid C D, Mackenzie D W

机构信息

Departamento de Microbiología e Inmunología, Facultad de Medicina y Odontología, Universidad del País Vasco, Bilbao.

出版信息

Rev Clin Esp. 1993 Jun;193(2):70-2.

PMID:8341817
Abstract

In this study, we have evaluated the usefulness of eight serologic tests in the diagnosis of a Candida tropicalis septicaemia in a patient with acute myeloid leukaemia. Among the tests used, detection of mannose and candida antigen in serum allowed a high degree of suspicion of infection, earlier than the isolation of this species on mycological cultures from blood or oesophagic samples. Detection of anti-C. albicans antibodies was useless but low titres of anti-C. tropicalis antibodies were observed. In spite of early diagnosis and antifungal treatment, the complication of the disseminated candidiasis with a Pseudomonas aeruginosa septicaemia, concluded with the patient's exitus.

摘要

在本研究中,我们评估了八项血清学检测对一名急性髓系白血病患者热带念珠菌败血症诊断的实用性。在所使用的检测中,血清中甘露糖和念珠菌抗原的检测比从血液或食管样本的真菌培养中分离出该菌种更早地提示高度感染疑似。抗白色念珠菌抗体的检测无用,但观察到了低滴度的抗热带念珠菌抗体。尽管进行了早期诊断和抗真菌治疗,但播散性念珠菌病合并铜绿假单胞菌败血症的并发症导致了患者死亡。

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