Royère D
Département de gynécologie-obstétrique et reproduction humaine, CHU Bretonneau, Tours.
Rev Prat. 1993 Apr 15;43(8):981-6.
Strategy for male infertility looks like a compromise between diagnosis methods with their efficacy and complexity and treatment with their own risks, cost, efficacy. Infertility duration as well as woman's fertility play a key role for such a strategy. Definitive infertility without any correction (secretory azoospermia) will be proposed for alternate projects. Some situations may benefit from specific therapy (hypogonadotropic hypogonadism, anejaculations or retrograde ejaculation). More frequently male hypofertility is suspected with non specific sperm alterations, then assisted reproductive technologies will be discussed. Intra-cervical way artificial insemination with husband semen may be proposed in case of hypospadias, anejaculation, retrograde ejaculation, small volume ejaculate or self-cryostored semen, however negative post-coital test, positive crossed penetration test and positive post-insemination test need to be confirmed. Intrauterine way enhance fertilizing probability by discarding cervical step. It will be justified in case of negative post-coital test as well as crossed penetration test except that sperm preparation allowed to inseminate 500,000 to 1 million motile spermatozoa. Both rigorous monitoring and synchronism between insemination and ovulation enhance the efficacy of IU AIH which allowed a two to four fold increase in the pregnancy rate on a total of six cycles. In vitro fertilization for male factor represent around 15% of all IVF attempts. Both decrease in the fertilization rate and the increase in the pregnancy rate by transfer as compared with tubal factor are well accepted. The fertilization failure remain difficult to explain and need to be cautiously confirmed. Thus IVF represent an actual fertilization test but remain limited by the heterogeneity of parameters under "male factor".(ABSTRACT TRUNCATED AT 250 WORDS)
男性不育症的治疗策略似乎是在诊断方法(及其有效性和复杂性)与治疗方法(及其自身风险、成本和有效性)之间进行权衡。不育持续时间以及女性的生育能力对这样一种策略起着关键作用。对于没有任何矫正可能的绝对不育症(分泌性无精子症),将建议采用替代方案。某些情况可能受益于特定治疗(低促性腺激素性性腺功能减退、不射精或逆行射精)。更常见的是,当怀疑男性生育力低下且伴有非特异性精子改变时,会讨论辅助生殖技术。对于尿道下裂、不射精、逆行射精、精液量少或自存冷冻精液的情况,可考虑采用丈夫精液进行宫颈内人工授精,不过性交后试验阴性、交叉穿透试验阳性和授精后试验阳性需要得到证实。子宫内人工授精通过省去宫颈环节提高了受精概率。在性交后试验和交叉穿透试验均为阴性的情况下,只要精子制备后能够授精50万至100万个活动精子,子宫内人工授精就是合理的。严格的监测以及授精与排卵之间的同步性提高了子宫内丈夫精液人工授精(IU AIH)的有效性,在总共六个周期中使妊娠率提高了两到四倍。因男性因素进行的体外受精约占所有体外受精尝试的15%。与输卵管因素相比,受精率下降以及通过移植使妊娠率提高这两点都得到了广泛认可。受精失败仍然难以解释,需要谨慎确认。因此,体外受精是一种实际的受精测试,但仍然受到“男性因素”下参数异质性的限制。(摘要截断于250字)