Mobbs B G, Chapman J A, Sutherland D J, Ryan E, Tustanoff E R, Ooi T C, Murthy P V
Department of Surgery, University of Toronto, Ontario, Canada.
Eur J Cancer. 1993;29A(9):1293-7. doi: 10.1016/0959-8049(93)90076-r.
Breast carcinoma oestrogen receptor (ER) and progesterone receptor (PgR) values obtained by radioligand binding assays have commonly been observed to have approximate log-normal distributions. We examined the distribution of log-transformed receptor values obtained by enzyme immunoassay for 5468 primary breast carcinomas in five Ontario laboratories. In each laboratory, it was found that the frequency histograms for the log transformed receptor values were not unimodal, and generally were suggestive of bimodality. This was not affected by stratification by age or inferred menopausal status (< or = 49, > or = 50 years), and could not be explained by kit characteristics. However, the low point in the distribution varied from 5 to 63 fmol/mg cytosol protein, depending on the receptor, patient age and laboratory. The tendency towards biomodality was more distinct for ER than for PgR. It remains to be determined whether the low points on the frequency histograms have clinical relevance for discriminating between hormone-sensitive and hormone-insensitive tumours.
通过放射性配体结合测定法获得的乳腺癌雌激素受体（ER）和孕激素受体（PgR）值通常被观察到具有近似对数正态分布。我们在安大略省的五个实验室中，检查了通过酶免疫测定法获得的5468例原发性乳腺癌的对数转换受体值的分布情况。在每个实验室中，发现对数转换受体值的频率直方图并非单峰的，并且通常提示双峰性。这不受年龄分层或推断的绝经状态（≤49岁，≥50岁）的影响，也无法用试剂盒特性来解释。然而，分布的最低点在5至63飞摩尔/毫克胞浆蛋白之间变化，这取决于受体、患者年龄和实验室。ER的双峰趋势比PgR更为明显。频率直方图上的最低点对于区分激素敏感和激素不敏感肿瘤是否具有临床相关性，仍有待确定。
