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吡咯抑素，一种来自克雷氏链霉菌的新型脂质过氧化抑制剂。分类学、发酵、分离、结构解析及生物学特性

Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.

作者信息

Kato S, Shindo K, Kawai H, Odagawa A, Matsuoka M, Mochizuki J

机构信息

Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jun;46(6):892-9. doi: 10.7164/antibiotics.46.892.

DOI:10.7164/antibiotics.46.892
PMID:8344870
Abstract

Pyrrolostatin, a new lipid peroxidation inhibitor, was isolated from the culture of Streptomyces chrestomyceticus EC40. The structure was determined to be 4-geranylpyrrole-2-carboxylic acid on the basis of its spectroscopic and physico-chemical properties. Pyrrolostatin inhibited lipid peroxidation in rat brain homogenate.

摘要

吡咯抑素是一种新型脂质过氧化抑制剂，从链霉菌EC40的培养物中分离得到。根据其光谱和物理化学性质，确定其结构为4-香叶基吡咯-2-羧酸。吡咯抑素可抑制大鼠脑匀浆中的脂质过氧化。

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