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吩嗪病毒素，一种来自链霉菌属的新型自由基清除剂。分类学、发酵、分离、结构解析及生物学特性。

Phenazoviridin, a novel free radical scavenger from Streptomyces sp. Taxonomy, fermentation, isolation, structure elucidation and biological properties.

作者信息

Kato S, Shindo K, Yamagishi Y, Matsuoka M, Kawai H, Mochizuki J

机构信息

Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.

出版信息

J Antibiot (Tokyo). 1993 Oct;46(10):1485-93. doi: 10.7164/antibiotics.46.1485.

DOI:10.7164/antibiotics.46.1485
PMID:8244877
Abstract

Phenazoviridin is a newly discovered free radical scavenger from microorganisms. It was isolated from the culture of Streptomyces sp. HR04. The structure of phenazoviridin was determined as 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid 6-deoxy-alpha-L-talopyranose ester on the basis of its spectroscopic and physico-chemical properties. The novel substance showed strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibited antihypoxic activity in mice.

摘要

吩嗪绿菌素是一种新发现的来自微生物的自由基清除剂。它是从链霉菌属菌株HR04的培养物中分离出来的。根据其光谱和物理化学性质，吩嗪绿菌素的结构被确定为6-(3-甲基-2-丁烯基)吩嗪-1-羧酸6-脱氧-α-L-塔罗吡喃糖酯。这种新物质对大鼠脑匀浆中的脂质过氧化表现出强烈的抑制活性，并在小鼠中表现出抗缺氧活性。

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