Coe C L
Department of Psychology, University of Wisconsin, Madison 53706.
Psychosom Med. 1993 May-Jun;55(3):298-308. doi: 10.1097/00006842-199305000-00007.
This review summarizes research from several laboratories that has assessed the influence of psychosocial factors on immune responses in nonhuman primates. These studies have demonstrated that the formation and disruption of social relationships should be viewed as significant psychobiological events with many immunologic sequelae, especially for the young monkey. Prolonged changes in leukocyte numbers, in vitro measures of lymphocyte function, and antibody responses to antigenic challenge have been reliably observed. There is also evidence in infant monkeys suggesting that normal maternal care may be important for the development and maintenance of the physiological set points for certain immune responses. Similarly, immune responses in adult monkeys can be affected by the level of aggression occurring within the group. Collectively, this research reiterates the important influence that psychosocial variables can have on basic physiological responses, particularly when social relationships are in the process of change.
本综述总结了多个实验室的研究，这些研究评估了社会心理因素对非人类灵长类动物免疫反应的影响。这些研究表明，社会关系的形成和破坏应被视为具有许多免疫后遗症的重大心理生物学事件，尤其是对幼猴而言。白细胞数量的长期变化、淋巴细胞功能的体外测量以及对抗抗原攻击的抗体反应已得到可靠观察。在幼猴中也有证据表明，正常的母性照料对于某些免疫反应的生理设定点的发展和维持可能很重要。同样，成年猴的免疫反应会受到群体内攻击水平的影响。总体而言，这项研究重申了社会心理变量对基本生理反应可能产生的重要影响，特别是当社会关系处于变化过程中时。
