Keown P A, Descamps B
Lancet. 1979 Jan 6;1(8106):20-2. doi: 10.1016/s0140-6736(79)90458-6.
Phagocytosis of altered red blood cells in vitro by mononuclear phagocytic cells is followed by profound depression of bystander lymphocytes' responses to antigen. Rapid endocytosis of transfused erythrocytes in vivo may transiently impair mononuclear phagocytic cell function, resulting in immunological unresponsiveness as observed in vitro. Transplantation at this time would be predicted to benefit from this attenuation of recipient immunocompetence, resulting in improved graft survival.
体外单核吞噬细胞对改变的红细胞进行吞噬作用后，旁观者淋巴细胞对抗原的反应会受到严重抑制。体内输血红细胞的快速内吞作用可能会短暂损害单核吞噬细胞功能，导致出现体外观察到的免疫无反应性。此时进行移植预计会受益于受体免疫能力的这种减弱，从而提高移植物存活率。
