多氯联苯混合物、海豹及人类体内非邻位和单邻位共平面多氯联苯的潜在毒性

Toxic potential of non-ortho and mono-ortho coplanar polychlorinated biphenyls in Aroclors, seals, and humans.

作者信息

Hong C S, Bush B, Xiao J, Qiao H

机构信息

Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.

出版信息

Arch Environ Contam Toxicol. 1993 Jul;25(1):118-23. doi: 10.1007/BF00230721.

DOI:10.1007/BF00230721

PMID:8346970

Abstract

Mono-ortho and non-ortho coplanar polychlorinated biphenyls (PCBs) were analyzed in Aroclors, seals, and humans by graphitized carbon, a recently developed HPLC method (Hong et al. 1992b) and high-resolution gas chromatography with electron capture detection (HRGC/ECD). The concentration data were multiplied by potency factors derived from aryl hydrocarbon hydroxylase (AHH) induction to give 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents. The ability to separate coplanar PCBs from the majority of PCBs has allowed the use of TCDD toxicity equivalence to compare the relative dioxin-like potency of PCB residues in the complex mixtures. The most active mixtures, Aroclors 1254, 1248, and 1242, contained 42-54% by weight of chlorine. The results demonstrate that the apparent dioxin-like potency of PCB residues in Aroclors, seals, and humans is dominated by three congeners, 3,3',4,4'-tetra-, 2,3,3'-4,4'-, and 3,3',4,4',5-pentachlorobiphenyl (IUPAC nos. 77, 105, 126).

摘要

通过石墨化碳、一种最近开发的高效液相色谱法（Hong等人，1992b）以及带电子捕获检测的高分辨率气相色谱法（HRGC/ECD），对多氯联苯（PCBs）中的单邻位和非邻位共平面多氯联苯在氯丹、海豹和人体中进行了分析。浓度数据乘以源自芳烃羟化酶（AHH）诱导的效力因子，得出2,3,7,8-四氯二苯并对二恶英（TCDD）当量。将共平面多氯联苯与大多数多氯联苯分离的能力使得能够利用TCDD毒性当量来比较复杂混合物中多氯联苯残留的相对二恶英样效力。活性最高的混合物，即氯丹1254、1248和1242，含氯量按重量计为42 - 54%。结果表明，氯丹、海豹和人体中多氯联苯残留的表观二恶英样效力由三种同系物主导，即3,3',4,4'-四氯联苯、2,3,3'-4,4'-五氯联苯和3,3',4,4',5-五氯联苯（国际纯粹与应用化学联合会编号77、105、126）。