Hong C S, Xiao J, Bush B, Shaw S D
Wadsworth Center, New York State Department of Health, Albany, USA.
Chemosphere. 1998 Mar;36(7):1637-51. doi: 10.1016/s0045-6535(97)10039-x.
Four non-ortho-, eight mono-ortho-, and two di-ortho-chlorinated congeners have been determined in fresh water and salt water mussels, fish, snapping turtles, mallard, seals, and in human milk and adipose tissue. The planar PCB congeners are separated from the remainder of PCBs by activated carbon chromatography or HPLC on porous graphitic carbon followed by gas chromatography with electron capture detection. PCB toxic equivalency factors (TEFs) recommended by WHO [1] for 3 non-ortho, 8 mono-ortho, and 2 di-ortho PCBs and a TEF for congener 81 suggested by Harris et al. [2] were used for calculation of the contribution to dioxin-like toxicity to each life form. In all the biota examined, PCB congener IUPAC number 126 was the major contributor to PCB toxic equivalents. Congeners IUPAC number 118, 114, 105, 156, 157, 77, 81, and 170 also contributed significantly to PCB toxic equivalents. The ability to separate out planar PCBs from the majority of PCBs has allowed the use of TCDD toxicity equivalence to compare the relative dioxin-like potency of PCB residues in various species from different locations.
在淡水和咸水贻贝、鱼类、鳄龟、野鸭、海豹以及人乳和脂肪组织中，已检测出四种非邻位、八种单邻位和两种双邻位氯化同系物。通过活性炭色谱法或在多孔石墨碳上进行高效液相色谱法，随后采用电子捕获检测气相色谱法，将平面多氯联苯同系物与其余多氯联苯分离。世界卫生组织[1]推荐的3种非邻位、8种单邻位和2种双邻位多氯联苯的多氯联苯毒性当量因子（TEF）以及哈里斯等人[2]提出的同系物81的TEF，用于计算对每种生命形式的二恶英样毒性的贡献。在所有检测的生物群中，国际纯粹与应用化学联合会（IUPAC）编号为126的多氯联苯同系物是多氯联苯毒性当量的主要贡献者。IUPAC编号为118、114、105、156、157、77、81和170的同系物对多氯联苯毒性当量也有显著贡献。从大多数多氯联苯中分离出平面多氯联苯的能力，使得可以使用2,3,7,8-四氯二苯并-p-二恶英（TCDD）毒性当量来比较来自不同地点的各种物种中多氯联苯残留物的相对二恶英样效力。
