Baker D M, Nguyen-Van-Tam J S, Smith S J
Department of Surgery, University of Nottingham Medical School, Queen's Medical Centre.
Epidemiol Infect. 1993 Aug;111(1):21-5. doi: 10.1017/s0950268800056636.
This paper describes a matched case-control study to determine the efficacy of BCG vaccine in preventing the occurrence of leprosy in southern Malaŵi, a previously unstudied area. The BCG immunization rate amongst 145 individuals with leprosy was 44.8%, compared to 62.5% in 290 matched controls. The protective efficacy of BCG vaccine against leprosy in this region was estimated to be 63.6%; smallpox immunization had no effect. These findings support the view that BCG vaccine should be considered as a control measure in areas where leprosy is endemic.
本文描述了一项配对病例对照研究，以确定卡介苗在预防马拉维南部（一个此前未被研究的地区）麻风病发生方面的疗效。145名麻风病患者的卡介苗接种率为44.8%，而290名配对对照者的接种率为62.5%。据估计，该地区卡介苗对麻风病的保护效力为63.6%；天花疫苗接种则无效果。这些发现支持了这样一种观点，即在麻风病流行地区，应将卡介苗视为一种控制措施。
