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本文引用的文献

1
BCG vaccination of children against leprosy: seven-year findings of the controlled WHO trial in Burma.儿童接种卡介苗预防麻风病:世界卫生组织在缅甸进行的对照试验七年结果
Bull World Health Organ. 1973;48(3):323-34.
2
BCG vaccination of children against leprosy. Preliminary findings of the WHO-controlled trial in Burma.儿童接种卡介苗预防麻风病。世界卫生组织在缅甸进行的对照试验的初步结果。
Bull World Health Organ. 1970;42(2):235-81.

儿童接种卡介苗预防麻风病:世界卫生组织在缅甸进行的对照试验九年研究结果

BCG vaccination of children against leprosy: nine-year findings of the controlled WHO trial in Burma.

作者信息

Bechelli L M, Lwin K, Gallego Garbajosa P, Uemura K, Sundaresan T, Tamondong C, Matejka M, Sansarricq H, Walter J

出版信息

Bull World Health Organ. 1974;51(1):93-9.

PMID:4281729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366256/
Abstract

The leprosy incidence rates so far in the vaccinated and unvaccinated children aged 5-9 and 10-14 years are similar. The BCG-vaccinated children aged 0-4 years at intake had an incidence rate lower than that of children in the control group. BCG vaccination did not protect household contacts or children aged 5-14 years not exposed in the household, and did not influence the distribution of the forms of leprosy in the cases detected. The lepromin reaction in relation to the age at intake was consistently stronger in the vaccinated children than in those of the control group; the younger the age group the more pronounced was the difference, which was only slight in the age group 10-14 years at intake. If the results of the late lepromin reaction are related to the age at onset (when the children are older than at intake), the differences between the BCG and the control groups tend to decrease. It does not seem that the BCG-vaccinated children suffer from a less serious form of leprosy than the nonvaccinated children (most of them nonreactors to tuberculin).

摘要

5至9岁和10至14岁已接种疫苗和未接种疫苗儿童的麻风发病率目前相似。入组时0至4岁接种卡介苗的儿童发病率低于对照组儿童。卡介苗接种并未保护家庭接触者或家庭中未接触过麻风的5至14岁儿童,也未影响所发现病例中麻风类型的分布。与入组年龄相关的麻风菌素反应在接种疫苗儿童中始终比对照组儿童更强;年龄组越小,差异越明显,在入组时10至14岁年龄组中差异仅轻微。如果迟发性麻风菌素反应结果与发病年龄(此时儿童年龄大于入组时)相关,卡介苗组与对照组之间的差异往往会减小。接种卡介苗的儿童所患麻风的病情似乎并不比未接种疫苗的儿童(其中大多数对结核菌素无反应)轻。