来自少花南蛇藤的具有潜在肿瘤促进抑制剂活性的倍半萜多元醇酯的结构
Structures of sesquiterpene polyol esters from Celastrus stephanotiifolius with potential tumor-promotion inhibitor activity.
作者信息
Takaishi Y, Ohshima S, Nakano K, Tomimatsu T, Tokuda H, Nishino H, Iwashima A
机构信息
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
出版信息
J Nat Prod. 1993 Jun;56(6):815-24. doi: 10.1021/np50096a003.
Esters of eight new ([1],[4-6], and [8-11]) and five known sesquiterpenenoid polyalcohols have been isolated from Celastrus stephanotiifolius. Their structures were established on the basis of chemical reactions and spectral analysis. The structural elucidation indicated that the structures of some related compounds should be revised. The isolated sesquiterpenes were observed to inhibit Epstein-Barr virus early antigen activation significantly at low doses.
从少花南蛇藤（Celastrus stephanotiifolius）中分离出了8种新的（[1]、[4 - 6]和[8 - 11]）以及5种已知的倍半萜多元醇酯。它们的结构是通过化学反应和光谱分析确定的。结构解析表明一些相关化合物的结构应予以修正。观察到分离出的倍半萜在低剂量时能显著抑制爱泼斯坦 - 巴尔病毒早期抗原的激活。
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