Chung M I, Gan K H, Lin C N, Ko F N, Teng C M
Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.
J Nat Prod. 1993 Jun;56(6):929-34. doi: 10.1021/np50096a018.
Various xanthones as well as quercetin have been shown to exhibit antiplatelet activity. A series of anthraquinones analogues structurally related to xanthones and a series of quercetin-related compounds were tested for their antiplatelet effects. Emodin, frangulin B, kaempferol tetraacetate, quercetin-3-O-galactoside octaacetate, rhamnazin triacetate, and rhamnetin tetraacetate were found to be potent antiplatelet agents, and 1,8-dihydroxy-6-methoxy-3-methylanthraquinone 8-O-rhamnosyl-(1-->2)-glucoside, rhamnustrioside undecaacetate, rutin decaacetate, and quercetin-3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-galactopyranos ide decaacetate showed significant antiplatelet effects. Quercetin showed vasorelaxing action in rat thoracic aorta.
多种氧杂蒽酮以及槲皮素已被证明具有抗血小板活性。测试了一系列与氧杂蒽酮结构相关的蒽醌类似物以及一系列与槲皮素相关的化合物的抗血小板作用。发现大黄素、弗郎鼠李素B、山柰酚四乙酸酯、槲皮素-3-O-半乳糖苷八乙酸酯、鼠李嗪三乙酸酯和鼠李素四乙酸酯是有效的抗血小板剂，并且1,8-二羟基-6-甲氧基-3-甲基蒽醌8-O-鼠李糖基-(1→2)-葡萄糖苷、鼠李糖三糖苷十一乙酸酯、芦丁十乙酸酯和槲皮素-3-O-(6-O-α-L-阿拉伯吡喃糖基)-β-D-半乳糖吡喃糖苷十乙酸酯显示出显著的抗血小板作用。槲皮素在大鼠胸主动脉中表现出血管舒张作用。
