Lin C N, Lu C M, Lin H C, Ko F N, Teng C M
National Taiwan University, Taipei, Republic of China.
J Nat Prod. 1995 Dec;58(12):1934-40. doi: 10.1021/np50126a023.
A new naphthalene derivative, isotorachrysone [1], was isolated from the stem bark of Rhamnus nakaharai along with several known compounds. The antiplatelet effects of isotorachrysone [1], isotorachrysone peracetate [2], 6-methoxysorigenin [3], quercetin 3-O-methyl ether [4], and quercetin 3-O-methyl ether peracetate [5] were studied using washed rabbit platelets. Of the compounds tested, 1, 2, 4, and 5 showed potent antiplatelet effects on arachidonic acid (AA-) and collagen-induced platelet aggregation. Compound 5 also showed potent antiplatelet effects on platelet-activating factor-(PAF-) induced platelet aggregation. Isotorachrysone [1] and its peracetate [2] were also studied for antiplatelet activity in human platelet-rich plasma (PRP) and both showed potent inhibition of the secondary aggregation induced by epinephrine. The antiplatelet effects of 1 and 2 are due partially to an inhibitory effect on thromboxane formation.
一种新的萘衍生物异鼠李素[1]，与几种已知化合物一起从鼠李科植物纳卡哈鼠李的茎皮中分离出来。使用洗涤过的兔血小板研究了异鼠李素[1]、全乙酸异鼠李素[2]、6-甲氧基异鼠李素[3]、槲皮素3-O-甲基醚[4]和全乙酸槲皮素3-O-甲基醚[5]的抗血小板作用。在所测试的化合物中，1、2、4和5对花生四烯酸（AA-）和胶原诱导的血小板聚集显示出强效的抗血小板作用。化合物5对血小板活化因子（PAF-）诱导的血小板聚集也显示出强效的抗血小板作用。还研究了异鼠李素[1]及其全乙酸酯[2]在富含人血小板血浆（PRP）中的抗血小板活性，两者均对肾上腺素诱导的二次聚集显示出强效抑制作用。1和2的抗血小板作用部分归因于对血栓素形成的抑制作用。
