Akine Y, Tokita N, Tokuuye K, Satoh M, Kobayashi T, Kanda K
Outpatient Clinic, National Cancer Center Hospital, Tokyo.
Jpn J Clin Oncol. 1993 Jun;23(3):145-8.
The present in vivo study estimates the dose resulting from the gadolinium neutron capture reaction and the gadolinium enhancement extent of the thermal neutron effect. The assay is based on the time required from cell inoculation to the formation of tumors with an arbitrary size of 200 mm2. Mice were inoculated subcutaneously with Ehrlich tumor cells with or without meglumine gadopentetate (1.2 mg 157Gd/0.2 ml), and were exposed to 1.1 x 10(12) thermal neutrons cm-2(n 8), or 3 MeV electrons at three dose levels (each n 10). To reach 200 mm2 in size, it took 18.8 days for tumors treated with neutrons only and 34.7 days for those treated with gadolinium and neutrons. From the time-dose relation obtained with 3 MeV electrons, the equivalent doses corresponding to delays of 34.7 and 18.8 days were 15.0 and 7.4 Gy, respectively. Thus, gadolinium enhanced the thermal neutron effect two-fold (15.0/7.4) in the present study.
本体内研究评估了钆中子俘获反应产生的剂量以及热中子效应的钆增强程度。该测定基于从细胞接种到形成大小为200平方毫米的任意大小肿瘤所需的时间。将接种了艾氏腹水瘤细胞的小鼠皮下注射钆喷酸葡胺（1.2毫克157钆/0.2毫升）或不注射，然后暴露于1.1×10(12)个热中子/平方厘米（n = 8），或三个剂量水平的3兆电子伏电子（每个n = 10）。仅用中子治疗的肿瘤达到200平方毫米大小需要18.8天，而用钆和中子治疗的肿瘤则需要34.7天。根据用3兆电子伏电子获得的时间-剂量关系，对应于34.7天和18.8天延迟的等效剂量分别为15.0和7.4戈瑞。因此，在本研究中，钆使热中子效应增强了两倍（15.0/7.4）。
