Better data analysis through data exploration.
作者信息
Hodge S E, Durner M, Vieland V J, Greenberg D A
出版信息
Am J Hum Genet. 1993 Sep;53(3):775-7.
Abstract
摘要
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1
Better data analysis through data exploration.通过数据探索实现更好的数据分析。
Am J Hum Genet. 1993 Sep;53(3):775-7.
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Distribution of lod scores under uncertain mode of inheritance.在不确定遗传模式下对数优势分数的分布。
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Joint linkage of multiple loci for a complex disorder.复杂疾病多个基因座的联合连锁
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The power to detect linkage in complex disease by means of simple LOD-score analyses.通过简单的对数优势分数分析来检测复杂疾病中连锁关系的能力。
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The score statistic of the LD-lod analysis: detecting linkage adaptive to linkage disequilibrium.连锁不平衡（LD）-对数优势（lod）分析的得分统计量：检测适应连锁不平衡的连锁关系。
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A quantitative trait locus mixture model that avoids spurious LOD score peaks.一种避免虚假LOD评分峰值的数量性状基因座混合模型。
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Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores.基于模型的多点对数优势分数的I型错误分布及大小：对多点改良分数的影响
Genet Epidemiol. 2006 Jul;30(5):447-58. doi: 10.1002/gepi.20157.
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Lod score curves for phase-unknown matings.未知交配阶段的连锁分析计分曲线。
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A multisample bootstrap approach to the estimation of maximized-over-models lod score distributions.
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Conclusion of LOD-score analysis for family data generated under two-locus models.基于双基因座模型生成的家系数据的对数优势评分（LOD-score）分析结论。
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引用本文的文献
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Reproducibility and complications in gene searches: linkage on chromosome 6, heterogeneity, association, and maternal inheritance in juvenile myoclonic epilepsy.基因搜索中的可重复性与并发症：青少年肌阵挛癫痫的6号染色体连锁、异质性、关联性及母系遗传
Am J Hum Genet. 2000 Feb;66(2):508-16. doi: 10.1086/302763.
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Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study.单基因座连锁分析在多种模型上最大化时的I型错误大小：一项模拟研究。
Am J Hum Genet. 1997 Jan;60(1):217-27.
3
Affecteds-only linkage methods are not a panacea.仅针对患者的连锁分析方法并非万灵药。
Am J Hum Genet. 1996 Apr;58(4):892-5.
本文引用的文献
1
Distribution of lod scores under uncertain mode of inheritance.在不确定遗传模式下对数优势分数的分布。
Am J Hum Genet. 1993 Feb;52(2):354-61.
2
Bipolar affective disorders linked to DNA markers on chromosome 11.双相情感障碍与11号染色体上的DNA标记有关。
Nature. 1987;325(6107):783-7. doi: 10.1038/325783a0.
3
Linkage analysis under "random" and "genetic" reduced penetrance.
Genet Epidemiol. 1989;6(1):259-64. doi: 10.1002/gepi.1370060145.
4
Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish.对老派阿米什人中11号染色体短臂基因座与双相情感障碍基因之间连锁关系的重新评估。
Nature. 1989 Nov 16;342(6247):238-43. doi: 10.1038/342238a0.
5
Adequacy of single-locus approximations for linkage analyses of oligogenic traits.
Genet Epidemiol. 1992;9(1):45-59. doi: 10.1002/gepi.1370090106.
6
There is more than one way to collect data for linkage analysis. What a study of epilepsy can tell us about linkage strategy for psychiatric disease.收集数据用于连锁分析的方法不止一种。一项关于癫痫的研究能告诉我们哪些关于精神疾病连锁策略的信息。
Arch Gen Psychiatry. 1992 Sep;49(9):745-50. doi: 10.1001/archpsyc.1992.01820090073012.
7
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods.家族间和家族内的异质性：有效的抽样策略及分析方法比较
Am J Hum Genet. 1992 Oct;51(4):859-70.
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