Zimmermann C W, Eblen F
Neurologische Universitätsklinik Tübingen.
Clin Investig. 1993 Jun;71(6):445-51. doi: 10.1007/BF00180057.
If weakness of the eye muscles remains the only symptom of myasthenia gravis (MG) for more than 2 years, the condition is operationally defined as ocular MG (OMG). A number of clinical, genetic, and immunological differences between this variant and generalized MG (GMG) have been described. We analyzed repertoires of autoantibodies against proteins of skeletal and extraocular muscle in sex- and age-matched groups of patients with either GMG or OMG (n = 10 in each group). All GMG sera detected a group of three proteins larger than 200 kDa which were not detected by any of the OMG sera. Two components with apparent molecular weights of 50 and 60 kDa were stained by seven of the ten OMG sera but by none of the GMG group. These antigens are probably soluble, cytoplasmatic proteins of the eye muscle. OMG sera, furthermore, detected a protein of about 45 kDa in the pellet fraction of eye muscle but failed to do so after adsorption with skeletal muscle fractions. We conclude that OMG and GMG sera contain autoantibodies of different specificities. Our findings further support immunological heterogeneity in MG.
如果眼肌无力作为重症肌无力（MG）的唯一症状持续超过2年，在临床上则定义为眼肌型重症肌无力（OMG）。已有文献描述了该型重症肌无力与全身型重症肌无力（GMG）在临床、遗传和免疫学方面的一些差异。我们分析了性别和年龄匹配的GMG或OMG患者组（每组n = 10）针对骨骼肌和眼外肌蛋白的自身抗体库。所有GMG血清均检测到一组分子量大于200 kDa的三种蛋白质，而所有OMG血清均未检测到。10份OMG血清中有7份能检测到表观分子量为50和60 kDa的两种成分，而GMG组均未检测到。这些抗原可能是眼肌的可溶性胞质蛋白。此外，OMG血清在眼肌沉淀部分检测到一种约45 kDa的蛋白质，但在用骨骼肌部分吸附后未能检测到。我们得出结论，OMG和GMG血清含有不同特异性的自身抗体。我们的研究结果进一步支持了MG的免疫异质性。
