Blom J, Hovind-Hougen K, Jensen H J, Birch-Andersen A
Acta Pathol Microbiol Scand A. 1977 Jan;85A(1):89-98. doi: 10.1111/j.1699-0463.1977.tb03871.x.
The morphology of lymph node tissue from normal hamsters and from hamsters experimentally infected with Treponema pertenue Gauthier was compared by means of light and electron microscopy. The capsules of the lymph nodes from infected hamsters showed an increased thickness in comparison with those of the non-infected animals. The infected lymph nodes differed from normal lymph nodes by small accumulations of neutrophilic leucocytes in the cortical areas. In addition, the amount of intercellular collagenous matrix present between large elongated cells was greatly increased in lymph nodes from infected animals. Electron microscopy of thin sections of infected lymph nodes showed intercellularly located treponemes in the leucocyte infiltration areas. These regions also showed the increased amounts of the collagenous matrix. Treponemes were occasionally found intracellularly in macrophages. These treponemes did not show their typically helical shape, but were present as spherical forms or cysts.
通过光学显微镜和电子显微镜，对正常仓鼠以及实验感染梅毒密螺旋体（Gauthier株）的仓鼠的淋巴结组织形态进行了比较。与未感染动物相比，感染仓鼠的淋巴结包膜厚度增加。感染的淋巴结与正常淋巴结的不同之处在于，皮质区域有少量嗜中性白细胞聚集。此外，在感染动物的淋巴结中，大的细长细胞之间的细胞间胶原基质数量大幅增加。对感染淋巴结薄切片的电子显微镜观察显示，在白细胞浸润区域细胞间存在梅毒螺旋体。这些区域的胶原基质数量也增加。偶尔在巨噬细胞内发现梅毒螺旋体。这些梅毒螺旋体未呈现其典型的螺旋形状，而是呈球形或囊肿状。
