Ito A, Hashimoto A
Department of Parasitology, Gifu University School of Medicine, Japan.
J Helminthol. 1993 Jun;67(2):165-8. doi: 10.1017/s0022149x00013079.
The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a Taenia taeniaeformis/rat system, since preparation of these oncospheres in vitro is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.
由于已知在体外制备这些六钩蚴非常简单，因此使用绦虫/大鼠系统评估了孵化但未激活的六钩蚴作为候选疫苗的有效性。研究结果如下：（1）用无活力六钩蚴接种的大鼠对攻击感染产生了完全抗性；（2）静脉注射诱导完全抗性最有效；（3）单个六钩蚴足以在感染大鼠中诱导完全抗性，而在接种疫苗的大鼠中分别需要约50个和500个无活力六钩蚴才能引发强烈和完全抗性。本文讨论了无佐剂的无活力六钩蚴的有效性。
