Am J Ophthalmol. 1993 Sep 15;116(3):286-96.
The objective of our clinic-based case-control study was to identify risk factors for branch retinal vein occlusion. Between 1986 and 1990 data were obtained at five clinical centers from 270 patients with branch retinal vein occlusion and 1,142 controls. Data were collected from interviews, clinical examinations, and laboratory analyses of blood specimens. An increased risk of branch retinal vein occlusion was found in persons with a history of systemic hypertension, a history of cardiovascular disease, an increased body mass index at 20 years of age, a history of glaucoma, and higher serum levels of alpha 2-globulin. Risk of branch retinal vein occlusion decreased with higher levels of alcohol consumption and high-density lipoprotein cholesterol. The data suggest a cardiovascular risk profile for patients with branch retinal vein occlusion and indicate that 50% of patients with branch retinal vein occlusion may be attributable to hypertension. Our findings support current public health recommendations to diagnose and treat hypertension, reduce weight, increase physical activity, and maximize serum high-density lipoprotein levels.
我们基于诊所的病例对照研究的目的是确定视网膜分支静脉阻塞的危险因素。1986年至1990年间，在五个临床中心收集了270例视网膜分支静脉阻塞患者和1142例对照的数据。数据通过访谈、临床检查以及血液标本的实验室分析收集。有系统性高血压病史、心血管疾病病史、20岁时体重指数增加、青光眼病史以及血清α2球蛋白水平较高的人，视网膜分支静脉阻塞风险增加。视网膜分支静脉阻塞风险随着饮酒量增加和高密度脂蛋白胆固醇水平升高而降低。数据表明视网膜分支静脉阻塞患者具有心血管疾病风险特征，并且指出50%的视网膜分支静脉阻塞患者可能归因于高血压。我们的研究结果支持当前关于诊断和治疗高血压、减轻体重、增加体育活动以及使血清高密度脂蛋白水平最大化的公共卫生建议。
