Rath E Z, Frank R N, Shin D H, Kim C
Kresge Eye Institute of Wayne State University School of Medicine, Detroit, MI 48201.
Ophthalmology. 1992 Apr;99(4):509-14. doi: 10.1016/s0161-6420(92)31940-2.
The authors conducted a case-control study of risk factors for retinal vein occlusions using 87 patients with vein occlusions, chosen randomly from photographic files from their institution between 1985 and 1990, and a control group of 85 subjects 38 years of age (the youngest individual in the vein occlusion group) or older, who were randomly selected from the records of two general ophthalmologists in the authors' department. Certain risk factors for retinal vein occlusion were highly significant when subjects with retinal vein occlusion were compared with the control group. These risk factors included systemic hypertension (odds ratio [OR], 3.86; 95% confidence interval [Cl], 2.08 to 7.16), open-angle glaucoma (OR, 2.89; 95% Cl, 1.38 to 6.05), and male sex (OR, 2.61; 95% Cl, 1.43 to 4.79). Race, presence of diabetes mellitus, history of coronary artery disease or stroke, and family history of diabetes, glaucoma, coronary artery disease, or stroke were not significant risk factors in the population studied. Logistic analysis of the risk factors showed no interactions. Risk factors for branch retinal vein occlusion and central retinal vein occlusion were identical.
作者进行了一项关于视网膜静脉阻塞危险因素的病例对照研究，研究对象包括87例静脉阻塞患者，这些患者是从1985年至1990年期间该机构的照片档案中随机选取的；还有一个对照组，由85名年龄在38岁（视网膜静脉阻塞组中最年轻的个体）及以上的受试者组成，他们是从作者所在科室的两位普通眼科医生的记录中随机选取的。当将视网膜静脉阻塞患者与对照组进行比较时，某些视网膜静脉阻塞的危险因素具有高度显著性。这些危险因素包括系统性高血压（优势比[OR]，3.86；95%置信区间[Cl]，2.08至7.16）、开角型青光眼（OR，2.89；95% Cl，1.38至6.05）以及男性（OR，2.61；95% Cl，1.43至4.79）。在所研究的人群中，种族、糖尿病的存在、冠状动脉疾病或中风病史以及糖尿病、青光眼、冠状动脉疾病或中风的家族史并非显著的危险因素。对这些危险因素进行逻辑分析显示不存在相互作用。视网膜分支静脉阻塞和视网膜中央静脉阻塞（的危险因素）是相同的。
