Garner W L, Rodriguez J L, Thomson P D, Brosius F C, Smith D J
Department of Surgery, University of Michigan Medical Center, Ann Arbor.
Ann Plast Surg. 1993 Jul;31(1):78-81.
A 35-year-old man with chronic renal failure developed toxic epidermal necrolysis due to combination antibiotic therapy for a community acquired pneumonia. During wound care for his toxic epidermal necrolysis, he developed massive bleeding, a 4 to 6 unit blood loss at each dressing change, due to uremia-associated platelet dysfunction and thrombocytopenia. After failure of standard therapy, the man was treated with intravenous triglycyl-lysine-vasopressin, a selective peripheral vasoconstrictor. Transfusion requirements stopped during treatment. This man went on to full recovery with complete wound healing. Triglycyl-lysine-vasopressin effectively reduced skin blood loss in this man with toxic epidermal necrolysis and an intrinsic hemostatic defect, and may be useful in other patients with cutaneous blood loss.
一名35岁的慢性肾衰竭男性因社区获得性肺炎接受联合抗生素治疗后发生中毒性表皮坏死松解症。在对其中毒性表皮坏死松解症进行伤口护理期间，由于尿毒症相关的血小板功能障碍和血小板减少症，他出现了大量出血，每次换药失血4至6个单位。在标准治疗失败后，该男子接受了静脉注射三甘氨酰赖氨酸加压素治疗，这是一种选择性外周血管收缩剂。治疗期间不再需要输血。该男子完全康复，伤口完全愈合。三甘氨酰赖氨酸加压素有效减少了这名患有中毒性表皮坏死松解症和内在止血缺陷患者的皮肤失血量，可能对其他皮肤出血患者有用。
