金黄色葡萄球菌对庆大霉素耐药的机制
Mechanisms of gentamicin resistance in Staphylococcus aureus.
作者信息
Dowding J E
出版信息
Antimicrob Agents Chemother. 1977 Jan;11(1):47-50. doi: 10.1128/AAC.11.1.47.
Abstract
Three clinical isolates of Staphylococcus aureus resistant to gentamicin and other aminoglycosides have been examined for antibiotic modifying enzymes. The strains contain a number of these enzymes, most of them similar to those commonly found in aminoglycoside-resistant gram-negative strains. All three strains (and a transductant derived from one of them) contain two enzymes mediating gentamicin resistance, an aminoglycoside 6'-N-acetyltransferase and a novel enzyme, gentamicin phosphotransferase.
摘要
已对三株对庆大霉素和其他氨基糖苷类抗生素耐药的金黄色葡萄球菌临床分离株进行了抗生素修饰酶检测。这些菌株含有多种此类酶，其中大多数与氨基糖苷类耐药革兰氏阴性菌株中常见的酶相似。所有三株菌株（以及其中一株的转导子）都含有两种介导庆大霉素耐药性的酶，一种氨基糖苷 6'-N-乙酰转移酶和一种新型酶，庆大霉素磷酸转移酶。
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