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醋酸铅和碳颗粒对大鼠肝脏中谷胱甘肽S-转移酶YfYf表达的影响。

Effect of lead acetate and carbon particles on the expression of glutathione S-transferase YfYf in rat liver.

作者信息

Boyce S J, Mantle T J

机构信息

Department of Biochemistry, Trinity College, Dublin, Ireland.

出版信息

Biochem J. 1993 Aug 15;294 ( Pt 1)(Pt 1):301-4. doi: 10.1042/bj2940301.

DOI:10.1042/bj2940301
PMID:8363583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1134598/
Abstract

Administration of intracardiac lead acetate produces a complex response in glutathione S-transferase (GST) YfYf expression in rat liver. The earliest response, an elevation of GST expression in Kupffer cells, can be mimicked by administering a suspension of carbon particles. The second effect of lead acetate administration is a marked elevation of GST YfYf in some but not all hepatocytes (the 'patchy' response). This effect is most marked 48-76 h after administration of a single dose of lead acetate and is easily detected by immunoblotting. Dexamethasone down-regulates the lead response in hepatocytes.

摘要

向大鼠心脏内注射醋酸铅会对其肝脏中谷胱甘肽S-转移酶（GST）YfYf的表达产生复杂的反应。最早的反应是枯否细胞中GST表达升高，给予碳颗粒悬液可模拟这一反应。注射醋酸铅的第二个效应是部分而非全部肝细胞中GST YfYf显著升高（“斑驳”反应）。在单次注射醋酸铅后48 - 76小时，这种效应最为明显，通过免疫印迹法很容易检测到。地塞米松可下调肝细胞中的铅反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/d42920fb8132/biochemj00105-0297-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/e59c86ae1be9/biochemj00105-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/239f26457e78/biochemj00105-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/a9a4593238d2/biochemj00105-0297-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/d42920fb8132/biochemj00105-0297-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/e59c86ae1be9/biochemj00105-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/239f26457e78/biochemj00105-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/a9a4593238d2/biochemj00105-0297-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d060/1134598/d42920fb8132/biochemj00105-0297-c.jpg

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本文引用的文献

1
The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin.人类谷胱甘肽S-转移酶P1-1基因：视黄酸和胰岛素对其表达的调节
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Glutathione transferases in primary rat hepatomas: the isolation of a form with GSH peroxidase activity.原代大鼠肝癌中的谷胱甘肽转移酶：具有谷胱甘肽过氧化物酶活性的一种形式的分离。
FEBS Lett. 1985 May 6;184(1):139-43. doi: 10.1016/0014-5793(85)80670-0.
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Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis.胎盘谷胱甘肽转移酶的纯化、诱导及分布：大鼠化学性肝癌发生过程中一种新的癌前细胞标志物酶
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10
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