吸烟和咀嚼烟草在口腔癌、咽癌和食管癌中的作用量化研究
Quantification of the role of smoking and chewing tobacco in oral, pharyngeal, and oesophageal cancers.
作者信息
Jayant K, Balakrishnan V, Sanghvi L D, Jussawalla D J
出版信息
Br J Cancer. 1977 Feb;35(2):232-5. doi: 10.1038/bjc.1977.31.
Abstract
The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for the oropharynx, and about 75% for the hypopharynx and larynx. In cancer of the oesophagus, however, the fraction is only 50%, showing that another factor or factors play an equal role in the aetiology of cancer of this site. At each of the sites studied, it was found that the two factors, smoking and chewing, acted synergistically, though in varying degrees.
摘要
首次对口腔癌、口咽癌、下咽癌、喉癌和食管癌中因吸烟和咀嚼烟草导致的病因分数进行了量化。已发现，吸烟和/或咀嚼烟草导致的总体病因分数在口腔癌中为70%，口咽癌中为84%，下咽癌和喉癌中约为75%。然而，在食管癌中，这一分数仅为50%，表明另一个或多个因素在该部位癌症的病因中起同等作用。在所研究的每个部位，均发现吸烟和咀嚼这两个因素存在协同作用，尽管程度不同。
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